Description: Nanotechnology presents a promising solution as it offers tailored interventions that can enhance crop yields, resilience, and nutrient use efficiency (NUE). By incorporating nonmaterial into various developmental stages, from seed to harvest, agricultural systems can mitigate stresses, optimize resource utilization, and bolster global food production amidst unprecedented environmental change.Nanoparticles are critical players in nanobiotechnology, owing to their unique physicochemical properties that offer versatility. Nanoparticle-mediated mechanisms can enhance biotic and abiotic stress tolerance in crops, while promoting soil health and fertility by enhancing nutrient retention and microbial activity in the rhizosphere.The synergistic integration of nanotechnologies holds immense promise for revolutionizing agricultural practices and ensuring the resilience and sustainability of agricultural production systems in the 21st century. This is essential for global food security amidst the challenges posed by climate change and population growth.